What Does NSI-189 Do

NSI-189 nootropic is popular among nootropics community. It is an experimental antidepressant by an American company called Neuralstem Inc. Developed by biotechnology companies for treating severe depression (MDD).

Its potential benefits in cognitive impairment and neurodegenerative diseases were also studied. A phase I trial on 41 healthy volunteers in 2011 showed no significant adverse reactions. This was followed by a phase Ib clinical trial of 24 participants, which began in 2012 and was completed in July 2014, and the results were published in December 2015.

These tests highlight the safety of NSI-189. In August 2020, a further phase 2 study involving 220 participants demonstrated the efficacy of NSI-189 as an adjuvant therapy for patients with MDD, with few side effects.

In addition to MDD, NSI-189 is studying its potential therapeutic effects on traumatic brain injury (TBI), Alzheimer's disease (AD), post-traumatic stress disorder (PTSD), stroke, and aging-related cognitive and memory decline.

Because of its great potential, the market demand is gradually increasing. As a NSI-189 powder manufacturer, Xi'an Sonwu Biotech Co., Ltd. is sure to supply top quality nootropics. If you are interested in nsi 189, feel free to contact Xi'an Sonwu Biotech Co., Ltd.

Certificate of Analysis

ANALYSIS	SPECIFICATION	RUSULT
Appearance	Off-White powder	Complies
Odor	Characteristic	Characteristic
Assay	99.00% Min	99.6%
Loss on drying	4.0% Max	0.32%
Heavy metals	10ppm Max	Complies
As	0.5ppm Max	Complies
Pb	1ppm Max	Complies
Hg	0.5ppm Max	Complies
Cd	1ppm Max	Complies
Total plate count	1,000cfu/g Max	Complies
Yeast & Mold	100cfu/g Max	Complies
E. Coli	Negative in 10g	Negative
Salmonella	Negative in 10g	Negative

NSI 189 Buy

Xi'an Sonwu Biotech Co., Ltd. has rich experience in global trade and health industry. Insist on faith-based and quality first is our company’s principle. Xi'an Sonwu strictly controls product quality, which means selection starts from raw material. Besides, Xi'an Sonwu handles every detail and reduce cost to the maximum extent, then our customers can get cost-effective product. Based on these, customers have given much good feedback to our products. So look for Xi'an Sonwu Biotech Co., Ltd. when you need NSI-189 nootropic.

Xi'an Sonwu completely makes sure product’s quality, so sample can be supplied. Here is the quantity.

Form	Sample Amount	The Minimum of Quantity
Powder	5g	10g
Bulk Capsules	200 capsules	200 capsules
Bottled Capsules	5 bottles	5 bottles

Customers’s Good Comment

OEM Service

Xi'an Sonwu Biotech Co., Ltd. not only can supply high quality NSI-189 powder, but also supply capsules form.

So any customers could customize capsules they want. And items below can be supplied.

1.Customized capsules shells (size, color, material)

2.Customized bottles(size, color, material, style)

3.Customized packaging(vacuum foil packaging, box, drum)

4.Customized label(paint film, matte film, optical mask)

NSI-189 Benefits

According to the scientific literature on NSI-189, the main research focus is to investigate its potential use as an adjuvant therapy for MDD. MDD is a debilitating mental illness characterized by persistent depression and lack of interest or fun in previously enjoyable activities.

Here are some of the clinical uses and other potential functions of NSI-189.

1. Major Depression Disorder (MDD).

One study used NSI-189 as a monotherapy for severe depression (MDD). Two hundred and twenty subjects were randomly assigned to receive 40 mg or 80 mg of NSI-189 or a placebo for 12 weeks.

The main outcome measure was the Montgomery Åsberg Depression scale (MADRS), an observation-based scale used to assess the severity of depression in adults.

The results showed that although the MADRS scores of both doses were not significantly lower than those of the placebo, the overall SDQ (depressive symptom questionnaire) decreased to 40 mg. This suggests that NSI-189 may still benefit patients with MDD, and further studies are needed to determine its efficacy.

In addition to the potential cognitive benefits, previous studies on neurogenic compounds such as NSI-189 have found promising results on mood improvement, further emphasizing their potential efficacy as a therapeutic agent for the treatment of MDD.

2. Blood-Brain Barrier (BBB).

BBB is a semipermeable membrane that acts as a protective shield around the brain, separating neurons from circulating blood cells.

An MCAo (middle cerebral artery occlusion) stroke destroys BBB, allowing toxins and antibodies to enter the nervous system and cause further damage. NSI-189 's ability to penetrate BBB even before the BBB breaks down caused by a stroke is one of the critical factors that make it so effective. This feature allows NSI-189 to stay in the brain for longer and more effectively initiate the process of tissue remodeling, helping to repair areas damaged after a stroke.

In addition, when NSI-189 terminated 12 weeks after a stroke, continuous behavioral improvements were observed in animals, suggesting that the drug may promote long-term healing and recovery even without daily treatment.

3. Enhanced Neurogenesis.

Naoki et al. showed that NSI-189 treatment successfully reversed cell death caused by oxygen-glucose deprivation (OGD). In addition, it increases the expression of Ki67 protein and the level of MAP2 density, which means that neural activity remains unchanged.

NSI-189 stimulates the upregulation of several critical neurogenic factors, such as BDNF (brain-derived neurotrophic factor) and SCF (stem cell factor). In addition, antibodies against these two factors prevent cell viability from saving OGD caused by NSI-189 therapy.

These findings suggest NSI-189 can provide a viable solution to protect and restore neuronal health by stimulating neurogenesis. It is worth noting that Naoki et al. It was found that hippocampal cells seemed to be particularly sensitive to the effect of NSI-189, and the experiment showed that BDNF and SCF increased after treatment with NSI-189.

NSI 189 Mechanism of Action

NSI-189 is thought to have neurogenic properties and may contribute to treating depression and other neurological diseases. It stimulates the growth of new neurons in the brain (called neurogenesis). This process helps rebuild connections between damaged brain cells and create new communication methods. This has been demonstrated by histopathological assessment, which is a microscopic examination of tissue samples to determine whether the cell or tissue structure has changed as a result of trauma, infection or disease.

One study showed that when NSI-189 was given orally to adult rats 6 hours after middle cerebral artery occlusion and NSI-189 was given daily for the next 12 weeks, MAP2 immunoreactivity demonstrated increased neurite growth.

The exact mechanism of neurogenesis stimulated by NSI-189 is not fully understood. However, it is thought to regulate the activity of neural stem cells (NSC) and progenitor cells (PC). NSC is an immature stem cell that can grow into various types of neurons, while PC is a more developed neural precursor.

By regulating the activity of these cells, the researchers hypothesized that NSI-189 could improve their ability to produce new neurons, thereby promoting neuronal growth and repair in areas of the brain affected by strokes or other injuries.

In addition to the effects on the growth of neurons, studies have shown that NSI-189 may also help to protect existing neurons from further damage. It does this through its antioxidation, which reduces oxidative stress in the brain caused by toxins or inflammation associated with damage or neurological diseases.

NSI 189 Dosage

The recommended dose for NSI-189 depends on several factors, including your age and health, as well as the specific benefits you want.

Generally, it is recommended that you start with a low dose of 20-40 mg a day and then gradually increase the dose. If there are no side effects, you can increase the dose to a maximum of 80-120 mg daily and take it in batches.

If you are utterly new to NSI-189, we do not recommend using it in combination with other cognitive enhancement compounds or drugs, as this increases your risk of adverse side effects. And it is better to consult the doctors before you take it.

Factory Environment

1.Xi'an Sonwu Biotech Co., Ltd has its own factory, so it has adequate stock. Also,Xi'an Sonwu has clean and tidy producing department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customer's need.

2.Xi'an Sonwu Biotech Co., Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service.

Certificate of Analysis

Logistics Record

In addition to guaranteeing the product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi’an Sonwu supply all kinds of couriers according to different needs.

Company Profile

Xi'an Sonwu Biotech Co., Ltd is a professional Chinese manufacturer and products supplier. It was founded in 2012, and located in Hi-Tech industrial Zone, Xi'an city, Shannxi province, China. lt pays all attention on development, research and production of food additives, plant extract, APl and other ingredients of health care products. The company supplies five kinds of raw material products: Anti-hair loss Powders, Nootropic, API, Muscle Building products, Plant Extract. Xi'an Sonwu sincerely believes that the premise of a great cooperation is best service and good quality. So, welcome your inquiry any time.

If you want to know NSI-189 nootropic price, feel free to contact Xi'an Sonwu Biotech Co., Ltd.

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